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Updated: Mar 27, 2026
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and antitumor activity evaluation of lamiridosin A derivatives
Yan-Xia Yang1, Jian-Wei Yan1, Fu-Lin Yan1
1a Pharmacy College , Xinxiang Medical University , Xinxiang 453003 , China.
Abstract:
A series of lamiridosin A derivatives were synthesized through simple procedures. Their antitumor activities were evaluated against EC9706, MGC803, and B16 cell lines in vitro. Several compounds showed potent antitumor activity, especially compound 10, with IC50 value of 2.36 μmol/L against MGC803 cell lines, is more potent than marketed positive drug 5-fluorouridine (5-FU).
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