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[Etiological analysis of 264 cases with chronic kidney disease stage 2 to 5 in children]

Qianfan Miao1, Qian Shen, Hong Xu2

  • 1Department of Nephrology and Rheumatology, Children's Hospital of Fudan University, Shanghai 201102, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics
|January 14, 2016
PubMed

Insights

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of chronic kidney disease (CKD) in children. Glomerular disease is more common in adolescents with CKD.

Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Clinical Pediatrics

Background:

  • Chronic kidney disease (CKD) in children poses significant health challenges.
  • Understanding the etiology of pediatric CKD is crucial for effective management.
  • Previous studies highlight varying causes of CKD across different pediatric age groups.

Purpose of the Study:

  • To investigate and summarize the primary causes of chronic kidney disease (CKD) in pediatric patients.
  • To analyze the etiological distribution of CKD stages 2-5 in children.
  • To identify age-related differences in the causes of pediatric CKD.

Main Methods:

  • Retrospective analysis of 264 pediatric CKD patients (stages 2-5) from January 2004 to December 2013.
  • Data collected from the Children's Hospital of Fudan University medical records.
  • Evaluation of patient age at diagnosis, primary diseases, and CKD staging according to NKF-K/DOQI guidelines.

Main Results:

  • Congenital anomalies of the kidney and urinary tract (CAKUT) were the most frequent cause (43.9%), followed by glomerular disease (23.1%).
  • CAKUT was prevalent in younger children (0-6 years), accounting for over 57% of cases.
  • Glomerular disease was the primary cause in adolescents (over 10 years), representing 49.2% of cases in this age group.

Conclusions:

  • CAKUT is the predominant etiology for pediatric CKD (stages 2-5), particularly in younger children.
  • Glomerular disease emerges as a significant cause of CKD in adolescent populations.
  • Age-specific etiological patterns underscore the need for tailored diagnostic and treatment approaches in pediatric CKD.
Abstract

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