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Comparison of the predictive value of plateletcrit with various other blood parameters in gestational diabetes
Ahmet Sahbaz1, Humeyra Cicekler2, Oner Aynioglu1
1a Department of Obstetrics and Gynecology, School of Medicine , Zonguldak Bulent Ecevit University , Kozlu , Zonguldak , Turkey and.
Insights
Plateletcrit, a complete blood count marker, shows promise for screening gestational diabetes (GDM). This study found plateletcrit more sensitive than other platelet indices for GDM diagnosis.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Metabolic Disorders
Background:
- Gestational diabetes mellitus (GDM) is a common pregnancy complication with adverse maternal and fetal outcomes.
- Low-grade chronic inflammation is implicated in GDM development.
- Platelets (PLT) are involved in coagulation and inflammation.
Purpose of the Study:
- To compare platelet indices in GDM patients versus healthy pregnant controls.
- To assess the diagnostic utility of platelet indices for GDM.
- To investigate the role of plateletcrit, mean platelet volume, and platelet distribution width in GDM.
Main Methods:
- Comparison of platelet indices (plateletcrit, MPV, PDW) between GDM patients and controls.
- Statistical analysis to determine significant relationships with GDM.
- Evaluation of sensitivity and specificity of platelet indices for GDM diagnosis.
Main Results:
- Significant associations were found between GDM and plateletcrit, mean platelet volume, and platelet distribution width (p < 0.001).
- Plateletcrit demonstrated higher sensitivity and specificity compared to other platelet indices.
- Plateletcrit provides more precise information than platelet count or mean platelet volume.
Conclusions:
- Platelet indices, particularly plateletcrit, may serve as valuable, inexpensive screening markers for GDM.
- These routinely measured parameters, often overlooked, can aid in early GDM detection.
- Plateletcrit shows potential as an adjunct to the oral glucose tolerance test for GDM screening.
Abstract:
Gestational diabetes is the most encountered metabolic disease in pregnancy and affects both the mother and fetus adversely. Low-grade subchronic inflammation is associated with gestational diabetes development. Platelets (PLT) play role in blood coagulation and inflammatory process. We aimed to compare the various platelet indices in patients with GDM and healthy pregnant controls and to determine whether PLT indices are useful in Gestational diabetes diagnosis. The present study was performed at the Zonguldak Bulent Ecevit University, School of Medicine, Department of Obstetrics and Gynecology. Statistically significant relationships with plateletcrit, mean platelet volume, and platelet distribution width and patients with GDM were found (p < 0.001). Plateletcrit had higher sensitivity and specificity than other platelet indices. Although plateletcrit is a largely unknown or an underestimated parameter in complete blood count, it gives more precise information than platelet count and mean platelet volume. Platelet-related indices and their determination are inexpensive and routinely ordered markers, the significance of which is often ignored. They may be useful in screening for gestational diabetes as an adjunct to oral glucose tolerance test.
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