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A New Fluorescent Sensor Based on Bisindolizine Derivative.

Anitha I1, Sheela Gopal M2, Divya Thomas3

  • 1Postgraduate and Research Department of Chemistry, Maharaja's College, Ernakulam, Kerala, 682011, India. dranithagirishkumar@gmail.com.

Journal of Fluorescence
|January 14, 2016
PubMed
Summary

A novel fluorescent sensor, 1,2,1

Keywords:
BisindolizineFe3+Fluorescence quenchingFluorescent sensorMicrowave synthesis

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Chemical Sensing

Background:

  • Development of selective and sensitive detection methods for metal ions is crucial.
  • Iron(III) (Fe(3+)) is an important ion in biological and environmental systems, necessitating accurate quantification.
  • Existing methods for Fe(3+) detection may lack selectivity or require complex procedures.

Purpose of the Study:

  • To develop a highly selective fluorescent sensor for the detection of Fe(3+) ions.
  • To investigate the sensing mechanism and optimize experimental conditions for the sensor.
  • To evaluate the sensor's applicability in real-world samples, specifically pharmaceutical analysis.

Main Methods:

  • Synthesis and characterization of the fluorescent sensor molecule, 1,2,1',2'-Tetramethoxycarbonyl-3,3'-bis(p-methylbenzoyl)-7,7'-bisindolizine (MBI).
  • Fluorescence spectroscopy was employed to study the interaction between MBI and Fe(3+) ions.
  • Optimization of experimental parameters such as pH, solvent, and concentration.
  • Determination of the linear detection range and limit of detection (LOD).
  • Investigation of the quenching mechanism through spectroscopic studies.

Main Results:

  • The developed MBI-based sensor exhibited excellent selectivity for Fe(3+) ions.
  • A linear relationship was observed between fluorescence quenching and Fe(3+) concentration within the range of 4.76 × 10(-3) to 2.00 × 10(-2) M.
  • The limit of detection (LOD) for Fe(3+) was determined to be 3.17 × 10(-3) M.
  • The quenching mechanism was elucidated, providing insights into the sensor-analyte interaction.
  • The sensor demonstrated successful application in the determination of Fe(3+) in pharmaceutical samples.

Conclusions:

  • A novel and selective fluorescent sensor for Fe(3+) detection has been successfully developed.
  • The MBI-based sensor offers a sensitive and reliable method for Fe(3+) quantification.
  • The sensor's ability to detect Fe(3+) in pharmaceutical samples highlights its practical utility in analytical chemistry.