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Transepidermal Water Loss in Neonates: Baseline Values Using a Closed-Chamber System
Teena R Mathanda1, Ramesh M Bhat1, Pavan Hegde2
1Departments of Dermatology, Venereology, and Leprosy, Father Muller Medical College Hospital, Kankanady, Mangalore, India.
Pediatric Dermatology
|January 14, 2016
Summary
Newborn skin barrier function, measured by transepidermal water loss (TEWL), is less developed than in adults. Higher TEWL in preterm and low birthweight neonates indicates increased skin sensitivity.
Area of Science:
- Dermatology
- Neonatology
- Pediatrics
Background:
- Transepidermal water loss (TEWL) is a key indicator of skin barrier function.
- Neonatal skin barrier is immature and susceptible to external factors.
- Understanding TEWL variations is crucial for appropriate infant skincare.
Purpose of the Study:
- To evaluate TEWL in neonates using a closed-chamber system.
- To assess TEWL variations based on delivery mode, prematurity, birth weight, and phototherapy.
- To compare neonatal TEWL with adult values.
Main Methods:
- Prospective study of 104 healthy neonates and 40 adults.
- Utilized a noninvasive, closed-chamber system (VapoMeter™).
- Analyzed TEWL across different neonatal subgroups and compared with adults.
Main Results:
- Significantly higher TEWL in neonates compared to adults.
- Elevated TEWL observed in preterm and low birthweight neonates.
- Higher TEWL in neonates receiving phototherapy, particularly at the antecubital fossa.
Conclusions:
- The closed-chamber system is a viable alternative for TEWL measurement.
- Higher neonatal TEWL indicates an adapting epidermal barrier post-birth.
- Newborn skin requires specialized care due to its sensitivity and developing barrier function.
