Understanding Biofilms in Chronic Sinusitis
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Updated: Mar 27, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
Published on: September 20, 2024
Bobby A Tajudeen1, Joseph S Schwartz2, James N Palmer3
1Department of Otorhinolarygology-Head and Neck Surgery, The University of Pennsylvania, 3400 Spruce Street, 5th Floor Silverstein Bldg., Philadelphia, PA, 19104, USA. bobby.tajudeen@uphs.upenn.edu.
Abstract:
Chronic sinusitis is a burdensome disease that has substantial individual and societal impact. Although great advances in medical and surgical therapies have been made, some patients continue to have recalcitrant infections. Microbial biofilms have been implicated as a cause of recalcitrant chronic sinusitis, and recent studies have tried to better understand the pathogenesis of chronic sinusitis as it relates to microbial biofilms. Here, we provide an overview of biofilms in chronic sinusitis with emphasis on pathogenesis, treatment, and future directions. In addition, recent evidence is presented, elucidating the role of bitter taste receptors as a possible key factor leading to biofilm formation.
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Biofilms
Microbiota of the Respiratory Tract
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
The Oral Microbiota

