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Updated: Mar 27, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
Dachuan Zhang1, Chunliang Xu1, Deepa Manwani2
1Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology.
Abstract:
Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vaso-occlusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.
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