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Updated: Mar 27, 2026
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Serum IL-17A in Behçet's disease
Nazan Emiroglu1, Fatma Pelin Cengiz1, Gul Bahar Erdem2
1Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey. Head of the Department: Prof. Nahide Onsun MD, PhD.
Introduction:
Behçet's disease is a chronic multisystem disease with spontaneous remissions and relapses. Several studies show that autoimmune mechanisms play an important role in the development of Behçet's disease. Activation of T cells and neutrophils is important in the pathogenesis of the disease. Interleukin 17 (IL-17) is a new cytokine that induces several types of cells to secrete proinflammatory cytokines in many inflammatory and autoimmune diseases.
Aim:
This study evaluated the serum levels of IL-17A in active and stable Behçet's disease patients.
Material And Methods:
Seventy-six patients who had active clinic findings of Behçet's disease were enrolled in our study. Seventy age- and sex-matched controls were also enrolled. Serum IL-17 levels were studied in peripheral venous blood samples.
Results:
No significant differences were found between active Behçet's disease patients and controls in terms of serum IL-17A (p > 0.05).
Conclusions:
These results suggest that IL-17A serum levels do not play an important role in active Behçet's disease.
