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Related Experiment Video

Updated: Mar 27, 2026

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Frontoparietal white matter integrity predicts haptic performance in chronic stroke.

Alexandra L Borstad¹, Seongjin Choi², Petra Schmalbrock³

¹Division of Physical Therapy, The Ohio State University, School of Health and Rehabilitation Science, 453 W. 10th Avenue, Columbus, OH 43210, United States.

Neuroimage. Clinical

|January 14, 2016

Summary

White matter integrity in the frontoparietal network is crucial for haptic performance after stroke. Specific tracts like thalamus to motor cortex (T-M1) are key targets for rehabilitation to improve touch sensation.

Keywords:

Diffusion MRI Frontoparietal network Hand Active Sensation Test Haptic performance Probabilistic tractography Sensorimotor Stroke Upper extremity

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Area of Science:

Neuroscience
Neurorehabilitation
Biomedical Engineering

Background:

Frontoparietal white matter facilitates complex haptic tasks, including somatosensory discrimination.
Understanding white matter integrity's role in post-stroke haptic deficits is crucial for effective rehabilitation.

Purpose of the Study:

To investigate the relationship between frontoparietal white matter microstructure and haptic performance in chronic stroke survivors.
To compare frontoparietal network integrity between individuals with stroke and age-matched controls.

Main Methods:

Diffusion-weighted MRI and probabilistic tractography were used to analyze 10 frontoparietal tracts in 19 stroke patients and 16 controls.
Haptic performance was assessed using the Hand Active Sensation Test (HASTe).
Diffusion metrics including fractional anisotropy (FA) and mean diffusivity (MD) were quantified for each tract.

Main Results:

Nine of ten frontoparietal tracts showed diminished structural integrity in the stroke group compared to controls.
Reduced white matter integrity (higher MD) in the ipsilesional thalamus to motor cortex (T-M1) tract correlated with poorer haptic performance.
Frontoparietal white matter integrity significantly predicted haptic performance variance in both stroke (90%) and control (87%) groups.

Conclusions:

Frontoparietal white matter integrity is vital for mediating haptic performance post-stroke.
The T-M1 and precuneus interhemispheric tracts are potential targets for interventions aimed at improving post-stroke haptic function.
Noninvasive brain stimulation techniques targeting these tracts may enhance tactile sensory recovery.