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Riboflavin Arrests Cisplatin-Induced Neurotoxicity by Ameliorating Cellular Damage in Dorsal Root Ganglion Cells

Maria Salman1, Imrana Naseem1, Iftekhar Hassan2

  • 1Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.

Biomed Research International
|January 14, 2016
PubMed

Insights

Riboflavin (RF) shows protective effects against Cis-Diamminedichloroplatinum II (CP) neurotoxicity in dorsal root ganglia (DRG) cells. The combination of RF and CP also enhanced cancer cell apoptosis, suggesting potential adjuvant use in chemotherapy.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Oncology

Background:

  • Cis-Diamminedichloroplatinum II (CP) is a widely used chemotherapy drug.
  • CP-induced neurotoxicity, particularly affecting dorsal root ganglia (DRG) cells, is a significant clinical challenge.
  • The protective mechanisms against CP neurotoxicity are not fully understood.

Purpose of the Study:

  • To investigate the potential neuroprotective role of riboflavin (RF) against CP-induced toxicity in DRG cells.
  • To evaluate the combined effect of RF and CP on DRG cells and cancer cell apoptosis.

Main Methods:

  • Established treatment protocols were applied to mice.
  • Histological analysis was used to assess DRG cell damage.
  • The study involved photoillumination and administration of RF and CP.

Main Results:

  • Riboflavin (RF) alone exhibited partial toxicity.
  • Combination therapy with RF and CP significantly reduced CP-induced damage in DRG cells.
  • The RF + CP combination effectively induced apoptosis in target cells, a desirable outcome for cancer treatment.

Conclusions:

  • Riboflavin (RF) demonstrates a protective effect against Cis-Diamminedichloroplatinum II (CP) neurotoxicity.
  • RF can serve as an effective adjuvant in CP-based chemoradiotherapy.
  • This combination may improve clinical outcomes in anticancer treatments.

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