Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Symmetric group sequential test designs.

S S Emerson1, T R Fleming

  • 1Department of Biostatistics, University of Washington, Seattle 98195.

Biometrics
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simulation study evaluating bio-creep risk in serial non-inferiority clinical trials for preservation of effect.

Statistics in biopharmaceutical research·2015
Same author

The design and conduct of clinical trials to limit missing data.

Statistics in medicine·2012
Same author

Design, conduct, and analysis of clinical trials in disease due to methicillin-resistant Staphylococcus aureus.

Clinical pharmacology and therapeutics·2009
Same author

Magnetic resonance imaging as a surrogate outcome for multiple sclerosis relapses.

Multiple sclerosis (Houndmills, Basingstoke, England)·2008
Same author

The impact of requisition design on laboratory utilization.

American journal of clinical pathology·2002
Same author

Group comparisons involving missing data in clinical trials: a comparison of estimates and power (size) for some simple approaches.

Statistics in medicine·2001
Same journal

Fast penalized generalized estimating equations for large longitudinal functional datasets.

Biometrics·2026
Same journal

Causally-interpretable random-effects meta-analysis.

Biometrics·2026
Same journal

Statistical inference for mean function of partially observed functional time series.

Biometrics·2026
Same journal

Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

Biometrics·2026
Same journal

Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

Biometrics·2026
Same journal

Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

Biometrics·2026
See all related articles

New symmetric group sequential designs offer efficient early stopping for clinical trials. These methods ensure ethical treatment availability while maintaining statistical power, improving upon existing designs.

Area of Science:

  • Biostatistics
  • Clinical Trial Design
  • Statistical Inference

Background:

  • Ethical considerations in Phase III clinical trials necessitate timely interim analyses for patient benefit.
  • Existing group sequential designs may exhibit asymmetry, potentially favoring early termination under specific hypotheses.
  • This can delay the availability of superior treatments to all participants.

Purpose of the Study:

  • To introduce a novel family of symmetric group sequential designs for clinical trials.
  • To enhance the efficiency and fairness of early stopping rules in hypothesis testing.
  • To provide practical tools for determining sample sizes and stopping boundaries.

Main Methods:

  • Development of a one-parameter family of symmetric one-sided group sequential designs.

Related Experiment Videos

  • Extension of symmetric tests to two-sided hypothesis testing.
  • Comparison of proposed designs with established Pocock and O'Brien-Fleming methods.

    • Main Results:

    • The proposed symmetric designs are nearly fully efficient regarding average sample number.
    • Symmetric two-sided group sequential tests demonstrate improved overall efficiency compared to existing methods.
    • Tables of critical values are provided for practical implementation.

    Conclusions:

    • Symmetric group sequential designs offer a more balanced and efficient approach to interim analyses in clinical trials.
    • These designs facilitate earlier access to effective treatments while preserving statistical integrity.
    • The provided tables and approximate tests support the application of these methods in various trial settings.