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The evaluation of spleen function in man.

M A Zago1

  • 1Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|January 1, 1989
PubMed
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Functional spleen evaluation in humans involves measuring spleen size, particle uptake, and red blood cell morphology. These methods help identify spleen dysfunction in conditions like sickle cell disease.

Area of Science:

  • Hematology
  • Medical Imaging
  • Immunology

Background:

  • Spleen function is crucial for blood filtering and immune response.
  • Acquired spleen dysfunction is linked to various diseases and conditions.
  • Standard evaluation methods include spleen volume, particle uptake, and erythrocyte morphology analysis.

Purpose of the Study:

  • To outline current methods for assessing human spleen function.
  • To identify common causes of acquired spleen abnormalities.
  • To correlate spleen size with spleen function in specific diseases.

Main Methods:

  • Measuring spleen volume using scintillation scanning.
  • Analyzing blood clearance curves of damaged autologous erythrocytes.
  • Counting erythrocytes with pits via interference contrast microscopy.

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Main Results:

  • Spleen volume, particle uptake, and erythrocyte morphology are key functional indicators.
  • Sickle cell diseases, inflammatory bowel diseases, and leukemia are frequent causes of spleen dysfunction.
  • Enlarged or normal-sized spleens with decreased function are observed in sickle cell syndromes.

Conclusions:

  • Current techniques provide valuable insights into spleen function.
  • Acquired spleen abnormalities have diverse etiologies.
  • A correlation between spleen size and function exists in certain hematological disorders.