A Pot-Economical Approach to the Total Synthesis of Sch-725674

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Synthetic Chemistry

Background:

• Antifungal compounds are crucial for treating infections.
• Efficient synthesis of complex molecules is vital for drug discovery.
• Sch-725674 is a potent antifungal agent requiring a viable synthetic route.

Purpose of the Study:

• To develop a pot-economical total synthesis of the antifungal Sch-725674.
• To streamline the synthetic process by minimizing isolation and purification steps.
• To establish an efficient asymmetric route for Sch-725674 production.

Main Methods:

• Utilized a phosphate tether-mediated one-pot sequential RCM/CM/chemoselective hydrogenation protocol.
• Employed a one-pot tosylation/acrylation sequence.
• Integrated a one-pot Finkelstein reaction/Boord olefination/acetonide deprotection procedure.

Main Results:

• Achieved a pot-economical total synthesis of antifungal Sch-725674.
• Successfully implemented multiple one-pot, sequential transformations.
• Developed an asymmetric route accomplished in seven pots with minimal purification.

Conclusions:

• The developed synthetic strategy is efficient and resource-conscious.
• The one-pot approach significantly reduces time and purification efforts.
• This synthesis provides a practical method for obtaining Sch-725674.