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Malignant Glomus Tumor Arising in a Long Standing Precursor Lesion
Ali Alexander Damavandy1, Florencia Anatelli, Maral Kibarian Skelsey
1*Department of Dermatology, Georgetown University Hospital, Washington Hospital Center, Washington, DC; and †Mid-Atlantic Pathology Services, Inc, Sterling, VA.
The American Journal of Dermatopathology
|January 14, 2016
Summary
Malignant glomus tumors are rare vascular cancers. This case highlights the malignant transformation of a benign glomus tumor, emphasizing the risk of metastasis for this rare condition.
Area of Science:
- Oncology
- Vascular Malignancies
- Dermatopathology
Background:
- Malignant glomus tumors are rare vascular neoplasms.
- Etiology is unclear, potentially arising de novo or from benign glomus tumors.
- These tumors carry a significant risk of metastasis.
Observation:
- An elderly woman presented with a painful, rapidly growing forearm tumor.
- The lesion was a 2.5-cm purple-brown dermal tumor.
- It evolved from a long-standing, seemingly benign lesion.
Findings:
- Excisional biopsy revealed a multilobular dermal tumor.
- Histopathology showed benign glomus cells alongside pleomorphic cells with high mitotic activity.
- Diagnosis of malignant glomus tumor was based on nuclear atypia and elevated mitotic rate.
Implications:
- This case illustrates malignant transformation of a presumed benign glomus tumor.
- Highlights a rarely reported phenomenon in vascular oncology.
- Aims to increase awareness of malignant glomus tumors and their metastatic potential.
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