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Effects of Egg Shell Membrane Hydrolysates on Anti-Inflammatory, Anti-Wrinkle, Anti-Microbial Activity and
Jinhee Yoo1, Kimoon Park1, Youngji Yoo1
1Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon 440-746, Korea.
Korean Journal for Food Science of Animal Resources
|January 14, 2016
Summary
Eggshell membrane hydrolysates (ESMH) show significant cosmetic benefits. Fraction I, particularly, demonstrates potent anti-inflammatory and anti-wrinkle properties, alongside antimicrobial and moisture-retaining effects for superior skin protection.
Area of Science:
- Biochemistry
- Dermatology
- Cosmetic Science
Background:
- Inflammation, wrinkles, and microbial infections are key concerns in skin aging and damage.
- Eggshell membrane hydrolysates (ESMH) are potential bioactive compounds for cosmetic applications.
- Understanding the specific effects of different molecular weight fractions of ESMH is crucial.
Purpose of the Study:
- To evaluate the efficacy of eggshell membrane hydrolysates (ESMH) and their fractions for cosmetic applications.
- To assess anti-inflammatory, anti-wrinkle, anti-microbial, and moisture-protective properties.
- To identify optimal fractions for skincare formulations.
Main Methods:
- Fractionation of ESMH into different molecular weight ranges (whole, >10 kDa, 3-10 kDa, <3 kDa).
- In vitro assessment of anti-inflammatory effects using Raw264.7 cells stimulated with LPS and IFN-γ.
- Enzyme inhibition assays for collagenase and elastase.
- Antimicrobial activity testing.
- In vivo moisture-protection evaluation on human skin.
Main Results:
- Whole ESMH and Fraction I (>10 kDa) effectively inhibited LPS and IFN-γ-induced inflammation.
- Fraction I demonstrated superior inhibition of collagenase and elastase activities.
- All ESMH fractions exhibited antimicrobial effects at tested concentrations.
- ESMH fractions enhanced skin moisture retention, forming a protective layer.
Conclusions:
- ESMH fractions, especially those with molecular weights around 10 kDa, possess significant anti-inflammatory, anti-wrinkle, and antimicrobial properties.
- These findings support the use of ESMH fractions as effective cosmetic agents for skin protection and anti-aging.
- The study highlights the potential of utilizing byproducts like eggshell membranes in high-value cosmetic ingredients.
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