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The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals

Renato Laks1, Lara Miguel Quirino Araújo1, Clineu de Mello Almada Filho1

  • 1Department of Geriatrics and Gerontology, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, Sao Paulo, SP, BR.

Einstein (Sao Paulo, Brazil)
|January 14, 2016
PubMed

Insights

High-density lipoprotein (HDL) cholesterol shows an inverse link with total mortality, while C-reactive protein is linked to increased mortality in longevous individuals. Both are promising predictors of cardiovascular risk in the elderly.

Area of Science:

  • Gerontology and Cardiovascular Health
  • Biomarkers and Longevity Research
  • Inflammation and Aging Studies

Background:

  • The relationship between lipoproteins, inflammatory markers, aging, and longevity is complex and debated.
  • Low high-density lipoprotein (HDL) cholesterol and high C-reactive protein (CRP) are frequently studied markers.
  • These markers may improve cardiovascular risk stratification, especially in octogenarians.

Purpose of the Study:

  • To review the scientific literature on the association between HDL cholesterol, inflammation, and longevity.
  • To evaluate the predictive value of HDL cholesterol and CRP for cardiovascular mortality in elderly populations.

Main Methods:

  • A literature review was conducted using PubMed.
  • Inclusion and exclusion criteria were applied to select relevant studies.
  • Thirty studies were selected, including systematic reviews, meta-analyses, longitudinal, and cross-sectional studies.

Main Results:

  • An inverse association was found between HDL cholesterol and total mortality.
  • An inverse association was observed between C-reactive protein and cardiovascular mortality.
  • A positive association was noted between C-reactive protein and mortality in longevous individuals.

Conclusions:

  • HDL cholesterol and C-reactive protein show potential as predictors of cardiovascular mortality.
  • These markers may be particularly valuable for assessing risk in elderly individuals with long lifespans.

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