Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

34.6K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
34.6K
Pain01:20

Pain

1.8K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.8K
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.9K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.9K
Lazarus's Cognitive Appraisal Theory01:20

Lazarus's Cognitive Appraisal Theory

2.6K
Cognitive psychologist Richard Lazarus proposed the cognitive-mediational theory of emotions, which emphasizes how individuals' assessments of stressors significantly affect their experience of stress. According to Lazarus, the stress response is determined by a two-step appraisal process: primary appraisal and secondary appraisal. These cognitive appraisals help individuals evaluate the potential impact of a stressor and determine the adequacy of their coping resources.
Primary Appraisal:...
2.6K
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

291
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
291
Counterfactual Thinking01:19

Counterfactual Thinking

350
Counterfactual thinking is a cognitive process wherein individuals mentally reconstruct alternative versions of past events, often beginning with “what if” or “if only.” This reflective mechanism plays a significant role in shaping emotional experiences and guiding future behavior. Though typically triggered by unfavorable or unexpected outcomes, counterfactual thinking can also emerge in mundane, everyday decisions and experiences, revealing its deep entrenchment in...
350

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative effectiveness and safety of pharmacological interventions for sleep outcomes in chronic non-cancer pain: a systematic review and network meta-analysis.

Sleep medicine reviews·2026
Same author

Farmers' Perspectives on Chronic Pain and Chronic Pain Management Strategies.

Journal of agromedicine·2026
Same author

Effect of depression screening on future depressive symptoms in a persistent pain population: mediation analysis.

Pain reports·2026
Same author

Towards global clinical practice guidelines for the management of non-specific low back pain in primary care: a review of current guideline recommendations and how they have changed over the last 30 years.

The Lancet. Rheumatology·2026
Same author

An investigation of a novel public health campaign to improve understanding of persistent pain.

Musculoskeletal science & practice·2026
Same author

A meta-model of low back pain to examine collective expert knowledge of treatment effects and their mechanisms.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026

Related Experiment Video

Updated: Mar 27, 2026

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm
09:00

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm

Published on: October 3, 2020

4.6K

Does changing pain-related knowledge reduce pain and improve function through changes in catastrophizing?

Hopin Lee1, James H McAuley, Markus Hübscher

  • 1Neuroscience Research Australia (NeuRA), Sydney, NSW, Australia Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia EMGO+ Institute, VU University Medical Centre, Amsterdam, the Netherlands The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia.

Pain
|January 14, 2016
PubMed
Summary
This summary is machine-generated.

Improving pain biology knowledge helps patients, but reducing catastrophizing thoughts does not mediate this effect on pain or function. Further research is needed to understand pain management fully.

More Related Videos

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

17.7K
Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.8K

Related Experiment Videos

Last Updated: Mar 27, 2026

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm
09:00

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm

Published on: October 3, 2020

4.6K
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

17.7K
Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.8K

Area of Science:

  • Pain research
  • Psychology
  • Medical education

Background:

  • Reconceptualizing pain through education improves patient knowledge, reduces catastrophizing, and enhances pain outcomes.
  • Causal links between pain knowledge, catastrophizing, and functional improvements require investigation.

Purpose of the Study:

  • To test if reduced catastrophizing mediates the relationship between improved pain knowledge and better pain/function.
  • To analyze the causal mechanism of a pain education intervention.

Main Methods:

  • Longitudinal mediation analyses on 799 patients undergoing a pain education intervention.
  • Data collected at baseline, 1, 6, and 12 months using validated questionnaires for pain knowledge, catastrophizing, pain intensity, and function.
  • Statistical adjustments for confounding variables.

Main Results:

  • Improved pain biology knowledge significantly reduced pain intensity (total effect = -2.20).
  • This pain reduction was not mediated by decreased catastrophizing (indirect effect = -0.16).
  • Similar non-mediating trends observed for functional outcomes.

Conclusions:

  • Changes in catastrophizing do not mediate the impact of pain knowledge on pain intensity or function.
  • The findings suggest alternative pathways or factors influencing pain management beyond catastrophizing reduction.
  • Patient-clinician relational factors may play a moderating role, warranting further exploration.