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Updated: Mar 27, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity
Galina Ling1, Eduard Ling2, Arnon Broides3
1a Department of Pediatrics D and Pediatric Gastroenterology Unit .
Abstract:
Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.
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