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Related Experiment Video

Updated: Mar 27, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

15.6K

Single Cell Mass Measurement Using Drag Force Inside Lab-on-Chip Microfluidics System.

Md Habibur Rahman, Mohd Ridzuan Ahmad, Masaru Takeuchi

    IEEE Transactions on Nanobioscience
    |January 14, 2016
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a microfluidics system for measuring single cell mass (SCM). The novel approach accurately quantifies SCM, revealing an exponential relationship between cell mass and size in yeast cells.

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    Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip
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    Area of Science:

    • Biophysics
    • Microfluidics
    • Cell Biology

    Background:

    • Single cell mass (SCM) is a critical intrinsic property influenced by various intracellular components and processes.
    • Accurate SCM measurement is essential for understanding cell physiology and has seen advancements in techniques.
    • Further development is needed to enhance SCM measurement technology for deeper intracellular analysis.

    Purpose of the Study:

    • To develop and validate a novel lab-on-chip microfluidics system for precise single cell mass measurement.
    • To investigate the relationship between single cell mass and cell size in Saccharomyces cerevisiae.
    • To elucidate intracellular properties through advanced SCM analysis.

    Main Methods:

    • A microfluidic system was designed utilizing a pressure-driven syringe micropump to generate drag force.
    • Newton's law of motion was applied to determine SCM based on cell motion observed via microscopy.
    • The system was calibrated using polystyrene particles of known mass and diameter.

    Main Results:

    • The microfluidics system was successfully calibrated using a 5.2 μm polystyrene particle with a known mass of 77.3 pg.
    • SCM measurements for Saccharomyces cerevisiae baker's yeast cells were performed, with a 4.4 μm cell measuring 2.12 pg.
    • A direct exponential correlation was observed between single yeast cell mass and increasing cell size.

    Conclusions:

    • The developed microfluidics system provides a reliable method for SCM measurement.
    • The findings confirm previously reported SCM ranges for yeast cells.
    • The study highlights a significant exponential relationship between cell size and mass in yeast, offering insights into cellular growth dynamics.