Related Experiment Video
Updated: Mar 27, 2026

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
Published on: September 20, 2016
[Pathway modification of industrial microorganisms to improve acid-stress tolerance]
Abstract:
Different types of acids from fermentation environment or industrial microorganisms exist during fermentation process. Acids may inhibit growth and metabolism of industrial strains, namely acid stress. The tolerance mechanisms of acid stress include regulation of intracellular proton concentration, protection and restoration of intracellular macromolecules, changes in cell membrane composition and acid stress response at whole cell level. Screening and modification methods have been applied to improve acid-stress tolerance of industrial strains for decades. In this review, we provide insights into acid-stress tolerance of industrial microorganisms and address the modification of microbial pathways to improve acid-stress tolerance.
Related Concept Videos
Bioreactor Controls-III
Production of Organic Acids
Production of Antibiotics
Scale-Up Processes
Microbes in Food Production
Microorganisms in Agriculture and Food industry

