Proton Pump Inhibitor Prophylaxis After Gastric Bypass Does Not Cause Hypomagnesemia
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Updated: Mar 27, 2026

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Thomas C C Boerlage1, Charlotte L E van Hees2, Alwin D R Huitema3
1Department of Internal Medicine, MC Slotervaart, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. thomas.boerlage@slz.nl.
Abstract:
Proton pump inhibitor (PPI)-induced hypomagnesemia is currently a major topic. Patients undergoing Roux-en-Y gastric bypass are generally prescribed PPI prophylaxis after surgery. We investigated the prevalence of hypomagnesemia in our bariatric population. We reviewed the files of 1000 postoperative patients for serum magnesium level during PPI use. We found only five cases of hypomagnesemia, none of which was evidently related to PPI use. We conclude that the risk of hypomagnesemia during 1 year of prophylactic PPI use after Roux-en-Y gastric bypass (RYGB) is minimal and laboratory screening is probably not necessary.
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