Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Integrated Neurological Change Score Is a Sensitive Neurological Composite Measure to Evaluate Cervical Spinal Cord Injury Trials.

Journal of neurotrauma·2026

Same author

Unsupervised Data Driven Clustering of the Neurological Assessments of People With Traumatic SCI Focusing on Sensorimotor Complete Injuries.

Neurorehabilitation and neural repair·2026

Same author

Sustained chlorhexidine susceptibility in clinical MRSA isolates despite recent exposure.

JAC-antimicrobial resistance·2026

Same author

Evidence for Increased High Alpha Intermuscular Coherence as a Measure of Reticulospinal Motor Drive.

The European journal of neuroscience·2026

Same author

Linking neurological status to functional outcomes in spinal cord injury: a multi-class, task-specific approach.

BMC biomedical engineering·2026

Same author

The role of sex hormones in neurological and functional recovery following spinal cord injury in females: a systematic review of the literature.

Spinal cord·2026

Search research articles

Related Experiment Video

Updated: Mar 27, 2026

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

Prolonged-release fampridine in multiple sclerosis: Improved ambulation effected by changes in walking pattern.

Björn Zörner¹, Linard Filli², Katja Reuter²

¹Department of Neurology, University Hospital Zurich, Zurich, Switzerland bjoern.zoerner@usz.ch.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|January 15, 2016

Summary

Prolonged-release fampridine (PR-fampridine) enhances walking speed and endurance in some multiple sclerosis (MS) patients. This treatment also leads to personalized gait pattern adjustments and increased daily physical activity in responders.

Keywords:

Clinical trial fampridine multiple sclerosis outcome measurement symptomatic treatment

More Related Videos

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Related Experiment Videos

Last Updated: Mar 27, 2026

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Area of Science:

Neurology
Rehabilitation Medicine
Pharmacology

Background:

Multiple sclerosis (MS) is a chronic neurological disease affecting mobility.
Prolonged-release fampridine (PR-fampridine), also known as 4-aminopyridine, is investigated for its potential to improve walking function in MS patients.
Some MS patients demonstrate improved walking speed on the timed 25-foot walk test (T25FW) with PR-fampridine treatment.

Purpose of the Study:

To comprehensively evaluate the effects of PR-fampridine on various aspects of walking function in MS.
To identify specific gait modifications associated with PR-fampridine treatment in MS patients.
To assess the impact of PR-fampridine on everyday physical activity levels.

Main Methods:

A prospective, randomized, placebo-controlled, double-blind, crossover Phase II study (FAMPKIN) was conducted.
Participants received either PR-fampridine (10 mg twice daily) or placebo for 6 weeks.
3D motion analysis assessed gait kinematics and kinetics; clinical outcomes included T25FW, 6-minute walk test (6MWT), and balance scales. Accelerometry measured physical activity.

Main Results:

Analysis included data from 55 MS patients, with 17 identified as timed-walk responders to PR-fampridine.
Significant improvements in walking speed (T25FW) and endurance (6MWT) were observed in the overall population and responders.
Individualized gait pattern alterations correlated with functional improvements, and responders showed increased daily physical activity.

Conclusions:

PR-fampridine effectively improves walking speed, endurance, and daily physical activity in a subset of MS patients.
The treatment induces subject-specific modifications in gait patterns.
PR-fampridine represents a potential therapeutic option for enhancing mobility and function in MS.