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Second-order motion compensated PRESS for cardiac spectroscopy.

Maximilian Fuetterer1, Christian T Stoeck1,2, Sebastian Kozerke1,2

  • 1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.

Magnetic Resonance in Medicine
|January 15, 2016
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Summary

Second-order motion compensation in PRESS MRI improves cardiac spectroscopy by enhancing signal-to-noise ratio and reducing variability in triglyceride quantification. This advanced technique ensures robust measurements throughout the cardiac cycle.

Keywords:
PRESScardiac motioncardiac spectroscopygradient moment nullingmotion compensationtriglyceride

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Cardiovascular Spectroscopy

Background:

  • Cardiac motion significantly degrades signal quality in magnetic resonance spectroscopy (MRS).
  • Conventional PRESS sequences struggle with motion artifacts, limiting quantitative analysis of cardiac metabolites.
  • Accurate assessment of triglyceride-to-water ratio (TG/W) is crucial for understanding cardiac metabolism.

Purpose of the Study:

  • To develop and validate a second-order motion-compensated PRESS sequence for robust cardiac spectroscopy.
  • To improve signal-to-noise ratio (SNR) and reduce variability in TG/W quantification.
  • To enable reliable single-voxel cardiac spectroscopy throughout the entire cardiac cycle.

Main Methods:

  • Designed and implemented bipolar FID spoiling gradient pairs for first and second-order motion compensation.
  • Integrated these gradients into a cardiac-triggered PRESS sequence on a clinical MRI system.
  • Validated the approach using a 3D cardiac motion model and in vivo measurements in healthy volunteers.

Main Results:

  • The proposed sequence achieved an average SNR increase of 32% (water) and 23% (triglyceride).
  • Significantly reduced variability in TG/W quantification (coefficient of variation: 0.1 ± 0.02 vs. 0.37 ± 0.26).
  • Demonstrated lower variability across different cardiac trigger delays.

Conclusions:

  • Second-order motion-compensated PRESS effectively mitigates cardiac motion artifacts during FID spoiling.
  • The sequence provides higher SNR and improved TG/W quantification stability.
  • This technique shows promise for assessing TG/W modulation during various physiological and pharmacological interventions.