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Updated: Mar 27, 2026
Cortical Source Analysis of High-Density EEG Recordings in Children
Published on: June 30, 2014
Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals:
Claudio Babiloni1, Alfredo Pennica2, Claudio Del Percio3
1Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS S. Raffaele Pisana, Rome, Italy.
Objective:
This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (<4 Hz) and alpha (8-13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status.
Methods:
Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.
Results:
Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p<0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p<0.05).
Conclusions:
This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.
Significance:
This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.
