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Singapore Cancer Network (SCAN) Guidelines for Front-Line Systemic Therapy of Newly Diagnosed Advanced Epithelial
Introduction:
The SCAN gynaecological cancers systemic therapy workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for front-line systemic therapy of advanced epithelial ovarian cancer.
Materials And Methods:
The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting.
Results:
Five international guidelines were evaluated- those developed by the National Comprehensive Cancer Network (2013), the European Society of Medical Oncology (2013), the National Institute of Health and Clinical Excellence (2011), the Scottish Intercollegiate Guidelines Network (2011) and the Greater Metropolitan Clinical Taskforce (2009). Recommendations on the role of systemic therapy with intravenous chemotherapy, intraperitoneal chemotherapy, anti-angiogenic agents and neoadjuvant chemotherapy in newly diagnosed advanced epithelial ovarian cancer were developed.
Conclusion:
These adapted guidelines form the SCAN Guidelines 2015 for front-line systemic therapy of advanced epithelial ovarian cancer.
Insights
Singapore Cancer Network (SCAN) developed clinical practice guidelines for advanced epithelial ovarian cancer treatment. These guidelines adapt international evidence for local use, focusing on front-line systemic therapy options.
Area of Science:
- Oncology
- Clinical Practice Guidelines
Background:
- The Singapore Cancer Network (SCAN) gynaecological cancers systemic therapy workgroup was formed to address the need for localized treatment protocols.
- Advanced epithelial ovarian cancer requires standardized, evidence-based front-line systemic therapy approaches.
Purpose of the Study:
- To develop Singapore Cancer Network (SCAN) clinical practice guidelines for the front-line systemic therapy of advanced epithelial ovarian cancer.
- To adapt existing international evidence-based guidelines to the local Singaporean context.
Main Methods:
- A modified ADAPTE process was employed to systematically evaluate and adapt international guidelines.
- Five key international guidelines from 2009-2013 were assessed for relevance and applicability.
Main Results:
- Recommendations were formulated regarding the use of intravenous chemotherapy, intraperitoneal chemotherapy, anti-angiogenic agents, and neoadjuvant chemotherapy.
- The evaluation considered guidelines from major international bodies including NCCN, ESMO, NICE, SIGN, and GCMTF.
Conclusions:
- The adapted guidelines, termed SCAN Guidelines 2015, provide a framework for front-line systemic therapy in advanced epithelial ovarian cancer.
- These guidelines aim to optimize patient care by integrating global best practices with local considerations.
