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Updated: Mar 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Pulmonary Langerhans cell histiocytosis: radiologic resolution following cessation of second hand smoking
Leith Sawalha1, Abhishek Kumar1, Ayesha Arshad2
1Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo and Western New York Veterans Administration Healthcare System, Buffalo, NY, USA.
Abstract:
We present a 65-year-old male former smoker with past medical history of renal cell carcinoma. Surveillance chest CT scan showed numerous progressive bilateral upper lobe predominant nodular cystic densities. A Video Assisted Thoracoscopic Surgery lung biopsy was diagnostic of Pulmonary Langerhans Cell Histiocytosis. Further questioning of the patient revealed exposure to second hand smoke from his wife. A repeat chest CT scan 6 months following cessation of all smoking exposure showed near complete resolution of the nodular densities. Our case report highlights the importance of early identification of second hand smoke exposure. Timely elimination of the exposure led to near complete radiologic resolution.
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