Peptic ulcer disease: new developments

The wide array of medications aimed at all levels of acid secretion and at multiple levels of tissue function makes the choice of appropriate treatment for individual patients a challenge. The breakthrough development of cimetidine, followed by the rapid proliferation of new H2-receptor antagonists, new insights into parietal cell function, and the growth in our understanding of mucosal defense will make the treatment of peptic ulcer disease the challenge of the 1990s.