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Updated: Mar 27, 2026

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
Published on: November 1, 2017
Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized doxorubicin and deuterated
S K Misra1, P Mukherjee2, A Ohoka1
1Departments of Bioengineering and Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Carle Foundation Hospital, 502 N. Busey St., Urbana, IL 61801, USA. dipanjan@illinois.edu.
Abstract:
Simultaneous tracking of nanoparticles and encapsulated payload is of great importance and visualizing their activity is arduous. Here we use vibrational spectroscopy to study the in vitro tracking of co-localized lipid nanoparticles and encapsulated drug employing a model system derived from doxorubicin-encapsulated deuterated phospholipid (dodecyl phosphocholine-d38) single tailed phospholipid vesicles.

