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Utility of in-house fluconazole disk diffusion susceptibility testing in the treatment of candidemia
David W Kubiak1, Dimitrios Farmakiotis2, Viktoria Arons3
1Department of Pharmacy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Division of Infectious Diseases, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Abstract:
Among 302 first candidemia episodes, 210 (69.6%) were initially treated with an echinocandin or polyene (E/P) antifungal drug. In 137 (72.5%) patients with fluconazole-susceptible isolates, treatment was changed to fluconazole based on disk diffusion susceptibility testing. Clinical outcomes were not compromised in patients receiving E/P who were de-escalated to fluconazole for treatment of candidemia based on disk diffusion results.
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