Related Experiment Video
Updated: Mar 27, 2026

Author Spotlight: Accelerating Diagnostic Accuracy with Direct Identification of Gram-Negatives from Blood Culture Bottles
Published on: May 24, 2024
What's in a Name? The Impact of Accurate Staphylococcus pseudintermedius Identification on Appropriate Antimicrobial
1Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA BBL7@cdc.gov.
Abstract:
Bacteria in the Staphylococcus intermedius group, including Staphylococcus pseudintermedius, often encode mecA-mediated methicillin resistance. Reliable detection of this phenotype for proper treatment and infection control decisions requires that these coagulase-positive staphylococci are accurately identified and specifically that they are not misidentified as S. aureus. As correct species level bacterial identification becomes more commonplace in clinical laboratories, one can expect to see changes in guidance for antimicrobial susceptibility testing and interpretation. The study by Wu et al. in this issue (M. T. Wu, C.-A. D. Burnham, L. F. Westblade, J. Dien Bard, S. D. Lawhon, M. A. Wallace, T. Stanley, E. Burd, J. Hindler, R. M. Humphries, J Clin Microbiol 54:535-542, 2016, http://dx.doi.org/10.1128/JCM.02864-15) highlights the impact of robust identification of S. intermedius group organisms on the selection of appropriate antimicrobial susceptibility testing methods and interpretation.
Insights
Accurate identification of Staphylococcus intermedius group bacteria, like Staphylococcus pseudintermedius, is crucial for detecting methicillin resistance. Correctly distinguishing these from Staphylococcus aureus ensures appropriate antimicrobial susceptibility testing and treatment decisions.
Area of Science:
- Clinical microbiology
- Bacterial identification
- Antimicrobial resistance
Background:
- Bacteria in the Staphylococcus intermedius group frequently possess mecA-mediated methicillin resistance.
- Accurate identification is essential to differentiate from Staphylococcus aureus, preventing misdiagnosis.
- Advances in species-level identification impact clinical laboratory practices.
Purpose of the Study:
- To highlight the impact of accurate Staphylococcus intermedius group identification on antimicrobial susceptibility testing (AST).
- To emphasize the importance of correct species identification for treatment and infection control.
- To inform changes in AST methods and interpretation guidance.
Main Methods:
- The study evaluated the implications of robust identification of Staphylococcus intermedius group organisms.
- It focused on the influence of accurate species identification on AST selection and interpretation.
- The research underscores the importance of reliable diagnostic methods.
Main Results:
- Accurate identification of Staphylococcus intermedius group bacteria is critical for detecting methicillin resistance.
- Misidentification as Staphylococcus aureus can lead to inappropriate treatment and control measures.
- Improved species-level identification necessitates updated AST guidelines.
Conclusions:
- Robust identification of Staphylococcus intermedius group bacteria is vital for accurate methicillin resistance detection.
- Correct species identification directly influences the choice and interpretation of antimicrobial susceptibility tests.
- Clinical laboratories must adapt to advancements in bacterial identification for effective patient care.
Related Concept Videos
Automated Microbial Diagnostics
Clinical Significance of Antibiotic Resistance
Differential Staining Technique
Mechanism of Antibiotic Resistance in MRSA
Urine Studies II: Urine Culture and Sensitivity Test
Methods of Classification and Identification

