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Aged Garlic Extract Modifies Human Immunity.

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Aged garlic extract (AGE) supplementation enhanced immune cell function in healthy adults. While not reducing illness frequency, AGE improved cold and flu symptom severity, suggesting immune support.

Keywords:
NK cellaged garlic extractcoldsfluhuman immunityγδ-T cell

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Area of Science:

  • Immunology
  • Nutritional Science
  • Human Health

Background:

  • Garlic possesses compounds that may modulate immune responses.
  • Innate immune cells, including gamma delta T (γδ-T) and natural killer (NK) cells, are crucial for pathogen defense and susceptible to dietary influences.

Purpose of the Study:

  • To review the effects of aged garlic extract (AGE) on immune cell function.
  • To investigate AGE's impact on cell proliferation, activation, inflammation, and its potential to mitigate cold and flu symptoms.

Main Methods:

  • A 90-day randomized, double-blind, placebo-controlled study involving 120 healthy adults (21-50 years).
  • Participants consumed 2.56 g AGE or placebo daily during the cold and flu season.
  • Immune cell function (γδ-T and NK cells) was assessed via flow cytometry, and cold/flu symptom severity was self-reported daily.

Main Results:

  • After 45 days, AGE consumption led to increased proliferation and activation of γδ-T and NK cells compared to placebo.
  • After 90 days, the AGE group experienced significantly reduced severity of cold and flu symptoms, including fewer symptoms, less suboptimal functioning, and fewer missed work/school days.

Conclusions:

  • Aged garlic extract (AGE) supplementation enhances the function of key immune cells (γδ-T and NK cells).
  • AGE may contribute to reduced severity of common respiratory infections like colds and flu, potentially by supporting immune function with less associated inflammation.