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Human amniotic membrane grafts in therapy of chronic non-healing wounds
Dusko Ilic1, Ljiljana Vicovac2, Milos Nikolic3
1Stem Cell Laboratories, Guy's Assisted Conception Unit, Division of Women's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK dusko.ilic@kcl.ac.uk.
Background:
Human amniotic membrane (HAM) has been embraced as a natural wound dressing almost exclusively in ophthalmology. Only recently, emergence of commercial HAM products prompted its use in growing range of indications, especially treatment of chronic non-healing wounds.
Sources Of Data:
ClinicalTrials.gov database and International Clinical Trials Registry Platform searched with key words 'human amniotic membrane' and 'chronic wounds'.
Areas Of Agreement:
HAM can be successfully used as a natural wound dressing to promote healing.
Areas Of Controversy:
It is still unclear, which preparation is more advantageous, cryopreserved HAM or dehydrated HAM.
Growing Points:
There are an increasing number of commercial HAM products and clinical trials for a variety of dermatological diagnoses.
Areas Timely For Developing Research:
In spite of easy procurement and low production costs, to our knowledge, there are currently only a few manufacturers of commercial HAM products tested in clinical trials for cutaneous wounds and all of them are located in the USA.
