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Bisphenol A exposure may increase the risk of development of atopic disorders in children
I-Jen Wang1, Chia-Yang Chen2, Carl-Gustaf Bornehag3
1Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan; Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Health Risk Management, China Medical University, Taichung, Taiwan.
Insights
Postnatal exposure to Bisphenol A (BPA) is linked to higher IgE levels and an increased risk of asthma in children, especially girls. This suggests BPA may contribute to the development of allergic diseases.
Area of Science:
- Environmental Health
- Pediatric Allergy
- Toxicology
Background:
- The impact of Bisphenol A (BPA) exposure on the development of atopic disorders remains largely unknown.
- Understanding this relationship is crucial for public health, particularly in pediatric populations.
Purpose of the Study:
- To investigate the association between postnatal Bisphenol A (BPA) exposure and allergic diseases in children.
- To examine the role of Immunoglobulin E (IgE) levels in the potential pathogenesis of BPA-related allergic diseases.
- To explore gender-specific differences in these associations.
Main Methods:
- A cohort of 453 children from Taiwan was studied, collecting urine and blood samples at ages 3 and 6 years.
- Urinary Bisphenol A glucuronide (BPAG) levels were quantified using UPLC-MS/MS.
- Multivariate regression and mediation analyses were employed to assess associations between BPAG, IgE levels, and allergic diseases, including asthma.
Main Results:
- Higher urinary BPAG levels at age 3 correlated positively with IgE levels at age 3 and 6, particularly in girls.
- BPAG levels at age 3 were significantly associated with an increased risk of asthma at both ages 3 and 6.
- Mediation analysis indicated that IgE levels account for approximately 70% of the effect of BPA exposure on asthma risk.
Conclusions:
- Postnatal Bisphenol A (BPA) exposure is associated with elevated IgE levels in children.
- BPA exposure may elevate the risk of developing allergic diseases, with a more pronounced effect observed in girls.
- These findings highlight the potential role of BPA as an environmental factor contributing to childhood allergies.
Background:
Little is known about the effect of Bisphenol A (BPA) on atopic disorders.
Objective:
To investigated the associations (i) between postnatal BPA exposure and allergic diseases in children; (ii) between BPA and IgE levels for the possible disease pathogenesis; and (iii) gender-based differences.
Methods:
A total of 453 children from Childhood Environment and Allergic Diseases Study cohort with urine and blood samples were recruited in Taiwan. Urinary BPA glucoronide (BPAG) levels were measured by UPLC-MS/MS at ages 3 and 6 years. The associations between BPAG levels at different ages and IgE levels and the development of allergic diseases were evaluated by multivariate linear regression and logistic regression. A mediation analysis was also conducted to evaluate how much risk of allergic diseases in relation to BPA exposure is explained by IgE changes.
Results:
The BPAG levels at age 3 were positively associated with IgE levels at age 3 (β=64.85kU/l per ln-unit increase BPAG level; 95% CI, 14.59-115.11kU/l). Stratified by gender, BPAG levels at age 3 were positively associated with IgE levels at age 3, particularly in girls (β=139.23kU/l; 95% CI, 57.38-221.09kU/l). Similar results were also found at age 6. Urinary BPAG levels at age 3 were significantly associated with asthma at ages 3 and 6, with OR (95%CI) of 1.29(1.08-1.55) and 1.27(1.04-1.55). We estimated that 70% of the total effect of BPA exposure on asthma is mediated by IgE levels.
Conclusions:
BPA exposures were associated with IgE levels and may increase the risk of development of allergic diseases in children particularly in girls.
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