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Related Experiment Videos

Oral controlled-release morphine and gut function: a study in volunteers.

P A Clyburn1, M Rosen

  • 1Anaesthetic Department, University Hospital of Wales, Health Park, Cardiff.

European Journal of Anaesthesiology
|September 1, 1989
PubMed
Summary

Oral controlled-release morphine significantly delayed small-intestine transit time (SITT) in healthy volunteers, with nausea reported by some. Further research is needed to compare these effects with other morphine formulations.

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Area of Science:

  • Pharmacology
  • Gastroenterology

Background:

  • Oral controlled-release morphine (MST) is used for pain management.
  • Understanding its gastrointestinal effects is crucial for patient care.

Purpose of the Study:

  • To investigate the impact of oral controlled-release morphine (MST) on gastric emptying and small-intestine transit time (SITT).
  • To compare these effects against a placebo in healthy volunteers.

Main Methods:

  • A double-blind, cross-over trial involving ten healthy volunteers.
  • Gastric emptying assessed via paracetamol absorption.
  • Small-intestine transit time (SITT) measured using breath hydrogen analysis after a carbohydrate meal.

Main Results:

  • No significant alteration in paracetamol absorption, indicating gastric emptying was not immediately affected.

Related Experiment Videos

  • Small-intestine transit time (SITT) was significantly prolonged in 80% of subjects.
  • Nausea was reported by 30% of participants following MST administration.

    • Conclusions:

    • Oral controlled-release morphine (MST) significantly delays small-intestine transit time (SITT).
    • Further studies are required to compare these findings with other morphine administration routes, such as intramuscular.
    • Nausea is a notable side effect of oral controlled-release morphine (MST).