Related Experiment Video
Updated: Mar 27, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities
Sabrin R M Ibrahim1,2, Gamal A Mohamed3,4
1Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah , Al Munawwarah 30078, Saudi Arabia (phone: +966-581-183034; fax:+966-484-75027). sabrinshaur@gmail.com.
Abstract:
Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti-HIV, and anti-parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment.
More Related Videos
Related Concept Videos
Physical Properties of Amines
Biosynthesis of Nucleic Acids
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Amino Acid Biosynthetic Pathways
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Drugs Affecting Neurotransmitter Synthesis

