Related Experiment Video
Updated: Mar 27, 2026
09:01
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
8.4K
Pediatric Asthma and Viral Infection
M Luz Garcia-Garcia1, Cristina Calvo Rey1, Teresa Del Rosal Rabes2
1Servicio de Pediatría, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
Archivos De Bronconeumologia
|January 15, 2016
Summary
Respiratory viral infections like RSV and rhinovirus are key triggers for infant wheezing and asthma. Bronchiolitis, often caused by these viruses, is linked to long-term respiratory issues, especially in genetically predisposed children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Respiratory Medicine
Background:
- Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are primary risk factors for wheezing in young children.
- Bronchiolitis, the most common acute respiratory infection in infants, is frequently caused by RSV (approx. 70%) and rhinovirus.
- The link between viral bronchiolitis and subsequent recurrent wheezing or asthma has been observed for decades, though causality remains debated.
Purpose of the Study:
- To explore the association between respiratory viral infections and the development of wheezing and asthma in children.
- To investigate the role of specific viruses, such as RSV and rhinovirus, in pediatric respiratory illnesses.
- To understand the potential mechanisms linking viral infections to chronic respiratory conditions like asthma.
Main Methods:
- Review of existing literature on respiratory viral infections, bronchiolitis, and asthma in pediatric populations.
- Analysis of epidemiological data linking viral etiologies to wheezing and hospitalization rates.
- Examination of immunological factors potentially mediating the relationship between viral infections and asthma development.
Main Results:
- Respiratory syncytial virus (RSV) and rhinovirus are significant contributors to infant bronchiolitis and subsequent wheezing.
- A strong association exists between rhinovirus-induced bronchiolitis and the development of recurrent wheezing and asthma.
- Respiratory viruses are identified in over 90% of children hospitalized for wheezing, highlighting their role in exacerbations.
Conclusions:
- Respiratory viral infections, especially RSV and rhinovirus, are strongly associated with wheezing and asthma development in children.
- Bronchiolitis, particularly when caused by rhinovirus, may indicate a predisposition to asthma.
- Altered immune responses to viral infections in genetically susceptible individuals are likely central to the viral infection-asthma link.
Keywords:
AsmaAsthmaBocavirus humanoBronchiolitisBronquiolitisHuman bocavirusHuman metapneumovirusMetapneumovirus humanoRespiratory syncytial virusRespiratory virusesRhinovirusRinovirusVirus respiratorio sincitialVirus respiratoriosMore Related Videos
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
32.4K
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
11.1K
Related Concept Videos
01:29Asthma-I: Introduction
3.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.7K
01:20Asthma: Pathogenesis and Management
1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
01:30Asthma-IV: Diagnostic and Management
3.3K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
01:26Asthma-II: Pathophysiology and Classification
4.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.8K
01:24Asthma-III: Symptoms and Complications
3.6K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.6K
01:30Asthma-IV: Nursing Management
4.0K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
4.0K