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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

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Ceftaroline Fosamil Use in 2 Pediatric Patients With Invasive Methicillin-Resistant Staphylococcus aureus Infections

Amanda W Williams1, Patrick M Newman1, Sara Ocheltree2

  • 1Department of Pharmacy, Huntsville Hospital for Women and Children, Huntsville, Alabama.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|January 15, 2016
PubMed

Insights

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in children can be serious. Vancomycin therapy failed in two pediatric cases, but ceftaroline fosamil successfully treated invasive CA-MRSA infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Antimicrobial Resistance

Background:

  • Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant cause of pediatric infections.
  • Increasing resistance to traditional antibiotics like vancomycin necessitates alternative treatment options.
  • CA-MRSA can lead to severe invasive infections, including osteomyelitis and septic shock.

Observation:

  • Two pediatric patients with invasive CA-MRSA infections experienced treatment failure with vancomycin.
  • Both patients presented with severe conditions including bacteremia, abscesses, osteomyelitis, and septic shock.
  • Ceftaroline fosamil was administered to both patients following vancomycin failure.

Findings:

  • Ceftaroline fosamil successfully treated invasive CA-MRSA infections in both pediatric patients.
  • No adverse effects were reported with ceftaroline fosamil treatment.
  • The cases demonstrate the potential efficacy of ceftaroline fosamil in vancomycin-resistant pediatric CA-MRSA infections.

Implications:

  • Ceftaroline fosamil shows promise as an alternative treatment for severe pediatric CA-MRSA infections.
  • Further clinical trials are warranted to establish the safety and efficacy of ceftaroline fosamil in pediatric populations.
  • These findings may guide future treatment strategies for challenging CA-MRSA cases in children.
Keywords:
ceftaroline fosamilchildmethicillin-resistant Staphylococcus aureusosteomyelitispediatrics

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