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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

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Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
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Minimum Requirements for Core Competency in Pediatric Pharmacy Practice.

Elizabeth A Boucher1, Margaret M Burke1, Peter N Johnson1

  • 1Pediatric Pharmacy Advocacy Group, Memphis, Tennessee.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|January 15, 2016
PubMed
Summary
This summary is machine-generated.

Pharmacy schools offer varied pediatric training, impacting new graduates' readiness for pediatric pharmaceutical care. The Pediatric Pharmacy Advocacy Group (PPAG) recommends core competencies for pharmacists caring for hospitalized children.

Keywords:
competenciespediatric pharmacyposition

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Area of Science:

  • Pharmacy Education
  • Pediatric Pharmaceutical Care
  • Healthcare Competencies

Background:

  • Colleges of pharmacy present inconsistent didactic and clinical pediatric training.
  • This leads to variability in new pharmacy graduates' knowledge, skills, and perceptions regarding pediatric pharmaceutical care.
  • Ensuring consistent, high-quality pediatric care for children requires addressing these educational disparities.

Purpose of the Study:

  • To highlight the variability in pediatric pharmacy education across pharmacy colleges.
  • To emphasize the need for standardized training in pediatric pharmaceutical care.
  • To advocate for the adoption of core competencies in pediatric pharmacy.

Main Methods:

  • The study reviews current educational practices in colleges of pharmacy concerning pediatric training.
  • It analyzes the impact of varying training hours on graduate preparedness.
  • It references the recommendations and endorsements of the Pediatric Pharmacy Advocacy Group (PPAG).

Main Results:

  • Significant variation exists in the hours dedicated to pediatric didactic and clinical education.
  • This inconsistency directly correlates with differences in new graduates' competence and confidence in pediatric care.
  • A gap is identified between current educational outcomes and the needs of pediatric patients.

Conclusions:

  • Standardized pediatric pharmacy education is crucial for improving patient care.
  • The Pediatric Pharmacy Advocacy Group (PPAG) advocates for minimum core competencies for all pharmacists in pediatric care.
  • Implementing these competencies will enhance the quality and consistency of pharmaceutical services for hospitalized children.