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Updated: Mar 27, 2026

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
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Patient-Centered Outcomes Following Thoracentesis.

A Christine Argento1, Terrence E Murphy2, Margaret A Pisani3

  • 1Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA.

Pleura (Thousand Oaks, Ventura County, Calif.)
|January 15, 2016
PubMed
Summary

Therapeutic thoracentesis improves dyspnea and mental quality of life for pleural effusion patients. However, significant 30-day mortality and intervention rates highlight the procedure's impact.

Keywords:
dyspneapleural effusionquality of lifethoracentesis

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Area of Science:

  • Pulmonology
  • Critical Care Medicine
  • Thoracic Surgery

Background:

  • Pleural effusions affect over 1.5 million individuals annually in the US, causing substantial morbidity.
  • Therapeutic thoracentesis offers respiratory improvement, but its comprehensive impact requires further investigation.

Purpose of the Study:

  • To evaluate patient-centered outcomes, including dyspnea, quality of life (QoL), and basic activities of daily living (BADLs).
  • To determine the rate of additional pleural interventions and 30-day mortality following thoracentesis.

Main Methods:

  • Prospective observational cohort study of adult patients undergoing thoracentesis.
  • Assessment of dyspnea (mBORG), QoL (SF-12), and BADLs pre- and post-procedure.
  • Multivariable logistic regression analysis to identify outcome predictors.

Main Results:

  • 28.2% of patients died within 30 days; 21.5% of survivors required additional pleural interventions.
  • Survivors showed sustained improvement in dyspnea and mental QoL, but limited improvement in physical QoL or BADLs.
  • Malignant effusions strongly predicted the need for reintervention (OR 16.92); hepatic hydrothorax and infectious etiologies also increased intervention rates.

Conclusions:

  • Thoracentesis provides sustained relief in dyspnea and mental QoL, irrespective of effusion etiology or fluid volume.
  • Improvements in physical QoL and BADLs were less common.
  • High 30-day mortality and reintervention rates underscore the significant morbidity and mortality associated with thoracentesis for pleural effusions.