Related Experiment Video
Updated: Mar 27, 2026

Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
Published on: May 25, 2015
Phrenic nerve palsy following interscalene brachial plexus block; a long lasting serious complication
Abstract:
Interscalene brachial plexus block (ISBPB) offers good analgesia for painful surgical procedures on the shoulder. We here describe two cases of long-term phrenic palsy following ISBPB that occurred in our practice in a relative short time period and both clearly illustrate the devastating impact of this complication for the patient. We will discuss the benefit of ISBPB in the context of the incidence and significant disability of hemi diaphragm paresis. Anesthesiologists must be aware of this complication and carefully weigh the advantages of ISPBP against the risks of this complication. When ISPBP is considered, the fact that the incidence of prolonged phrenic nerve palsy may be higher than previously expected should be taken into account carefully. A reevaluation on the indication and patient selection of ISBPB may even be warranted.
Related Concept Videos
Spinal Nerves: Plexus I
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
Spinal Nerves: Plexus II
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Depolarizing Blockers: Pharmocokinetics
Depolarizing Blockers: Mechanism of Action
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...

