Related Experiment Video
Updated: Aug 5, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
Published on: November 21, 2017
[Fatal hyperpyrexia in an adolescent patient with severe burns after a traffic accident]
T Jaehn1, R Sievers2, A Junger3
1Universitätsklinik für Plastische, Wiederherstellende und Handchirurgie, Zentrum für Schwerbrandverletzte, Paracelsus Medizinische Privatuniversität, Klinikum Nürnberg, Nürnberg, Deutschland. tobias.jaehn@klinikum-nuernberg.de.
Abstract:
After a motorcycle accident a 16-year-old patient suffered severe burns to 40.5 % of the total body surface area (TBSA) of which 37 % were deep subdermal burns. After tangential and partly epifascial necrosectomy, Integra® was used as a temporary dermis replacement material for the lower extremities, combined with extensive negative pressure wound therapy (NPWT). In the further course of the treatment the patient developed uncontrollable hyperpyrexia with a fatal outcome. Possible influencing factors, such as the dermis replacement material combined with NPWT over large areas as well as the differential diagnoses propofol infusion syndrome, heatstroke and malignant hyperthermia are discussed.
Related Concept Videos
Increased Body Temperature
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Decreased Body Temperature
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Types of Fever
Here are the different types of fever:
Homeostatic Imbalances in Body Temperature

