Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

132
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
132
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Allergic Reactions02:06

Allergic Reactions

33.5K
Overview
33.5K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

169
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
169
Hypersensitivities01:30

Hypersensitivities

8.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.1K
Overview
86.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ribosomal protein S25 promotes cell cycle entry for a productive BK polyomavirus infection.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025
Same author

Arthroscopic management and recent advancements in the treatment of temporomandibular joint disorders.

The British journal of oral & maxillofacial surgery·2024
Same author

Very Elevated IgE, Atopy, and Severe Infection: A Genomics-Based Diagnostic Approach to a Spectrum of Diseases.

Case reports in immunology·2021
Same author

Arthroscopic diagnosis and medical management of calcium pyrophosphate deposition disease in the temporomandibular joint.

International journal of oral and maxillofacial surgery·2020
Same author

New technique for removing bone covering miniplates and screws.

The British journal of oral & maxillofacial surgery·2020
Same author

Risk factors for community-associated Clostridioides difficile infection in young children.

Epidemiology and infection·2019
Same journal

Single-Center Experience in Pediatric Lung Transplantation: Clinical Characteristics, Survival, and Post-Transplant Morbidity.

Pediatric transplantation·2026
Same journal

The Missing Link Between HLA Mismatch and Graft Failure: The Role of Donor-Specific Antibodies.

Pediatric transplantation·2026
Same journal

Truth or Consequences Revisited: Policymaking in Modern Organ Transplant.

Pediatric transplantation·2026
Same journal

First Single-Center Experience of Minimally Invasive Pediatric Living Donor Liver Transplantation in China.

Pediatric transplantation·2026
Same journal

Liver Retransplantation in Pediatric Recipients: A 20-Year Single-Center Experience With 25 Cases.

Pediatric transplantation·2026
Same journal

The Use of Ambulatory Blood Pressure Monitoring in Pediatric Heart Transplant Recipients.

Pediatric transplantation·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.8K

Food allergies developing after solid organ transplant.

J M Needham1, S K Nicholas2, C M Davis2

  • 1Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Pediatric Transplantation
|January 16, 2016
PubMed
Summary
This summary is machine-generated.

Food allergy is a growing concern after solid organ transplant, especially in children. Awareness of donor allergies and new-onset allergies is crucial for recipient health.

Keywords:
T lymphocytesimmunosuppressionpediatric liver transplantationpractice guidelinessolid organ transplantationtacrolimus

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

13.0K
Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.5K

Related Experiment Videos

Last Updated: Mar 27, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.8K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

13.0K
Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.5K

Area of Science:

  • Immunology
  • Transplantation
  • Allergy

Background:

  • Food allergy is an emerging complication following solid organ transplantation (SOT).
  • It is more prevalent in liver transplant recipients, particularly in pediatric populations, with reported frequencies ranging from 5% to 38%.

Purpose of the Study:

  • To review recent literature on food allergy after SOT.
  • To discuss the epidemiology, proposed mechanisms, and clinical implications of post-transplant food allergy.

Main Methods:

  • Literature review of recent reports on food allergy after solid organ transplantation.
  • Analysis of epidemiological data and proposed etiological mechanisms.
  • Discussion of clinical implications for patient management.

Main Results:

  • Food allergy is a recognized morbidity after SOT, with higher incidence in pediatric liver transplant recipients.
  • Multiple potential mechanisms are suggested, but a unified explanation is lacking.
  • Post-transplant food allergies can range from requiring dietary changes to life-threatening reactions.

Conclusions:

  • Food allergy is a significant concern in SOT recipients, necessitating awareness among healthcare providers and patients.
  • Understanding the epidemiology and mechanisms is vital for developing effective management strategies.
  • Early recognition and management are essential due to potential severe consequences.