Related Experiment Video
Updated: Mar 27, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.9K
[Update 2016 - Immunotherapy for urothelial carcinoma]
M Retz1, J E Gschwend1, S C Schmid2
1Urologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Deutschland.
Der Urologe. Ausg. A
|January 16, 2016
Summary
Advanced bladder cancer, a type of urothelial carcinoma, has a poor prognosis. This review covers standard chemotherapy and emerging immune therapies, including biological mechanisms and drugs in clinical trials for bladder cancer treatment.
Area of Science:
- Oncology
- Immunology
Background:
- Advanced urothelial carcinoma of the bladder presents an aggressive clinical challenge with limited treatment options.
- Platinum-based chemotherapy remains a cornerstone of treatment for advanced bladder cancer.
- Recent advancements have shifted focus towards immunomodulatory therapies.
Purpose of the Study:
- To provide a comprehensive overview of current therapeutic strategies for advanced urothelial carcinoma.
- To review the biological mechanisms underlying immunotherapies for bladder cancer.
- To summarize the status of immuno-oncological drugs in clinical trials.
Main Methods:
- Literature review of established therapies and ongoing clinical trials.
- Analysis of biological mechanisms relevant to bladder cancer immunotherapy.
- Synthesis of data on immuno-oncological drugs and their clinical evaluation.
Main Results:
- Established standard therapies include surgery and platinum-based chemotherapy.
- Emerging immunotherapies are being investigated for their efficacy and safety.
- Several immuno-oncological drugs are currently in various phases of clinical trials.
Conclusions:
- The treatment landscape for advanced bladder cancer is evolving with the integration of immunotherapy.
- Understanding the biological mechanisms is crucial for optimizing immuno-oncological drug development.
- Clinical trials are essential for validating novel therapies and improving patient outcomes.
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