Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

6.6K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.6K
Bone Remodeling01:40

Bone Remodeling

41.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.0K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.3K
9.3K
Bone Disorders01:29

Bone Disorders

7.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.4K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone response to intermittent parathyroid hormone (PTH) is both genetic and sex specific.

bioRxiv : the preprint server for biology·2026
Same author

Anti-IsdB Antibody-Secreting Cells Found in S. aureus-Infected Periprosthetic Bone Marrow: Case Series of Total Hip Arthroplasty Patients.

Medical research archives·2026
Same author

Dual-Scale StaphAIR: Predictive Modeling for the Diagnosis of <i>S. aureus</i> Infection via Simultaneous Detection and Quantification of Cytokines and Antibodies.

Analytical chemistry·2026
Same author

Genes, other than Muc5b, are associated with bleomycin-induced lung injury.

Communications biology·2026
Same author

COMPREHENSIVE GENETIC INVESTIGATION REVEALS HETEROGENEOUS PATHWAYS TO OBSTRUCTIVE SLEEP APNEA.

medRxiv : the preprint server for health sciences·2026
Same author

GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.

Genome biology·2025

Related Experiment Video

Updated: Mar 27, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.6K

How do bisphosphonates affect fracture healing?

Stephen L Kates1, Cheryl L Ackert-Bicknell2

  • 1Dept. of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA USA.

Injury
|January 16, 2016
PubMed
Summary
This summary is machine-generated.

Bisphosphonates (BPs) are safe for acute fracture healing in humans. However, long-term use or atypical fractures may negatively impact bone healing and remodeling.

Keywords:
bisphosphonatedelayed healingfracturefracture healing

More Related Videos

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

3.5K
Establishing a Diaphyseal Femur Fracture Model in Mice
05:46

Establishing a Diaphyseal Femur Fracture Model in Mice

Published on: December 9, 2022

3.3K

Related Experiment Videos

Last Updated: Mar 27, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.6K
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

3.5K
Establishing a Diaphyseal Femur Fracture Model in Mice
05:46

Establishing a Diaphyseal Femur Fracture Model in Mice

Published on: December 9, 2022

3.3K

Area of Science:

  • Orthopedics
  • Pharmacology
  • Bone Biology

Background:

  • Bisphosphonates (BPs) are widely used to treat conditions with reduced bone mineral density, such as osteoporosis.
  • BPs inhibit bone resorption, a critical process in fracture healing.
  • Their impact on fracture healing has been extensively studied in preclinical models.

Purpose of the Study:

  • To evaluate the influence of bisphosphonates on human fracture healing.
  • To differentiate effects based on timing of use (de novo vs. long-term) and fracture type (typical vs. atypical).

Main Methods:

  • Review of preclinical animal models investigating bisphosphonate effects on fracture callus formation and remodeling.
  • Analysis of clinical data on fracture healing in patients using bisphosphonates, considering de novo use and long-term exposure.
  • Examination of fracture healing in cases of atypical fractures associated with bisphosphonate use.

Main Results:

  • Animal models show larger fracture calluses and delayed remodeling from woven to lamellar bone with bisphosphonate treatment, but no delay in callus formation.
  • De novo bisphosphonate therapy initiated after a typical fracture in humans does not significantly affect healing.
  • Long-term bisphosphonate use is rarely associated with atypical fractures and delayed healing.
  • Bisphosphonates appear safe for acute fracture management in human extremities.

Conclusions:

  • Bisphosphonates demonstrate safety in the acute management of upper and lower extremity fractures in humans.
  • While effects of long-term bisphosphonate use on typical fracture healing remain largely unknown, they appear to negatively influence healing in the context of atypical fractures.