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Related Experiment Videos

Establishment and functional implications of B-cell connectivity.

D Holmberg1, A Andersson, L Carlsson

  • 1Institute for Applied Cell and Molecular Biology, University of Umeå, Sweden.

Immunological Reviews
|August 1, 1989
PubMed
Summary

The natural antibody repertoire exhibits high connectivity, based on self-interactions and conserved evolutionary properties. This forms a pool of naturally activated lymphocytes crucial for immune network stability and preventing autoimmunity.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • The normal immune system, particularly the B-cell compartment, possesses a natural antibody repertoire.
  • Understanding the structural properties of this repertoire is key to comprehending immune system function.

Purpose of the Study:

  • To elucidate the fundamental properties of the natural antibody repertoire.
  • To explore the basis of connectivity within the immune system and its evolutionary conservation.

Main Methods:

  • Discussion of structural aspects of the normal immune system.
  • Analysis of the properties of the natural antibody repertoire, including connectivity and interactions.
  • Consideration of evolutionary selection and ontogenetic expression of antibody V-genes.

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Main Results:

  • The natural antibody repertoire is characterized by high connectivity within the immune system and with other organismal components.
  • This connectivity is based on self-self interactions, degeneracy, and somatically selected interactions.
  • Evolutionary conservation ensures these properties, leading to early expression of specific antibody V-genes in ontogeny.

Conclusions:

  • A conserved pool of highly connected, naturally activated lymphocytes (10-15% of total lymphocytes) is maintained throughout ontogeny.
  • This pool is essential for maintaining normal immune network dynamics.
  • This cellular compartment may play a critical role in preventing autoimmune aggression.