Relationship between high sensitivity troponins and estimated glomerular filtration rate
Related Experiment Video
Updated: Mar 27, 2026
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Tuncay Guclu1, Serkan Bolat1, Mehmet Şenes1
1Department of Medical Biochemistry, Ankara Training and Research Hospital, Ministry of Health, Ankara 06340, Turkey.
Insights
High sensitivity troponin T (hs-cTnT) levels increase with declining kidney function, unlike troponin I (hs-cTnI), which is unaffected by estimated glomerular filtration rate (eGFR). This impacts acute coronary syndrome diagnosis in patients with chronic kidney disease.
Area of Science:
- Cardiology
- Nephrology
- Clinical Chemistry
Background:
- Diagnosis of acute coronary syndrome (ACS) is complicated by elevated troponin levels in chronic kidney disease (CKD) patients.
- Elevated cardiac troponin concentrations in CKD can mimic ACS, leading to diagnostic challenges.
Purpose of the Study:
- To compare high sensitivity troponin T (hs-cTnT) and troponin I (hs-cTnI) across different estimated glomerular filtration rate (eGFR) categories.
- To assess the impact of renal function on both hs-cTnT and hs-cTnI levels.
Main Methods:
- 119 outpatients were stratified into four groups based on eGFR: <30, 30-60, 60-90, and >90 mL/min/1.73m².
- Cardiac troponin T and I concentrations were measured concurrently in all patient groups.
Main Results:
- All patients with eGFR <30 mL/min/1.73m² had hs-cTnT above the decision point.
- Only 2 patients in the eGFR <30 group had hs-cTnI above the decision limit (40 ng/L).
- A significant negative correlation was observed between eGFR and hs-cTnT (R²=0.625), but not between eGFR and hs-cTnI (R²=0.013).
Conclusions:
- hs-cTnT levels significantly increase as eGFR decreases.
- hs-cTnI levels are not significantly affected by changes in eGFR.
- These findings highlight differential behavior of troponin assays in patients with impaired renal function, impacting ACS diagnosis.
Background:
Diagnosis of acute coronary syndrome may be challenging because of high troponin concentrations in patients with chronic kidney disease.
Objective:
the aim of this study is to investigate the difference between high sensitivity troponin T and troponin I in four groups of patients separated according to eGFR values and the effect of renal function both on troponin T and troponin I.
Methods:
119 outpatients were divided into 4 groups according to their eGFR values as Group 1: eGFR<30, Group 2: eGFR between 30 and 60, Group 3: eGFR between 60 and 90 and Group 4: eGFR >90mL/min/1.73m(2). The cardiac troponin T and I concentrations were measured concurrently.
Results:
Troponin T values of all patients who have eGFR values lower than 30mL/min/1.73m(2) were above the decision point, but cTnI values of only 2 patients were above the decision limit (40ng/L) in this group. There was a strong and significant negative relationship between eGFR and hs-cTnT [log(y)=2.3-0.72log(x); R(2)=0.625] whereas there was no significant relationship between eGFR and hs-cTnI [log(y)=1.28-0.08log(x); R(2)=0.013] when eGFR was taken into consideration as a continuous variable.
Conclusion:
In this study, we found that cTnT increases with decreasing eGFR values, but cTnI is not affected by the change in eGFR values.
Related Concept Videos
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
01:25Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
01:28Glomerular Filtration Rate and its Regulation
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
01:24Serum Studies: Renal Function Tests
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...