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Biochemical Markers of Renal Function
Danijela Krstic1, Nenad Tomic, Branimir Radosavljevic
1Institute of Medical Chemistry, School of Medicine, University of Belgrade, Višegradska 26, 11 000, Belgrade, Serbia. danijela.krstic@med.bg.ac.rs.
Current Medicinal Chemistry
|January 16, 2016
Summary
New kidney biomarkers aid in early detection and management of acute kidney injury (AKI) and chronic kidney disease (CKD). These markers improve diagnosis, predict progression, and assess treatment response, offering advantages over traditional serum creatinine tests.
Area of Science:
- Nephrology
- Biomarker Discovery
- Clinical Chemistry
Background:
- Kidney damage from various factors can lead to acute kidney injury (AKI) or chronic kidney disease (CKD).
- Renal function biomarkers in urine and serum are crucial for assessing injury severity and guiding therapy.
- Serum creatinine remains a common but limited biomarker for glomerular filtration rate.
Purpose of the Study:
- To review key renal biomarkers for kidney diseases.
- To classify biomarkers into functional, up-regulated proteins, enzymes, and cell cycle arrest types.
- To discuss biomarker properties, roles, and clinical utility in managing kidney injury.
Main Methods:
- Literature review of studies on renal biomarkers.
- Classification of biomarkers based on their function and expression.
- Analysis of biomarker properties and physiological roles.
Main Results:
- Numerous urinary and serum proteins have been identified as potential biomarkers for AKI and CKD.
- These novel biomarkers enable earlier and more accurate detection of kidney disease.
- Biomarker values can predict disease risk, progression, and response to therapy.
Conclusions:
- Novel renal biomarkers offer significant improvements over traditional markers like serum creatinine.
- These biomarkers are vital for precise diagnosis, prognosis, and personalized treatment of kidney diseases.
- Further investigation into biomarker utility across diverse clinical settings is warranted.
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