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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice.

Yong-qing Lu1, Xie-chao He1, Ping Zheng2

  • 1State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China Yunnan Key Laboratory of Animal Reproduction, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.

Molecular Human Reproduction
|January 16, 2016
PubMed
Summary
This summary is machine-generated.

The maternal effect gene Mater is crucial for maintaining oocyte quality in aging mice. Its depletion leads to reduced centromere cohesion and chromosomal abnormalities, contributing to age-related decline.

Keywords:
Materaneuploidycohesionmaternal ageingoocyte

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Area of Science:

  • Reproductive biology
  • Molecular genetics
  • Cell biology

Background:

  • Age-related decline in oocyte quality is a significant concern in reproductive health.
  • Premature loss of centromere cohesion is a key characteristic of declining oocyte quality with age.
  • The maternal effect gene Mater (maternal antigen that embryos require, also known as Nlrp5) is essential for early embryonic development and its expression decreases with maternal aging.

Purpose of the Study:

  • To investigate the role of the maternal effect gene Mater in the age-related decline of mouse oocyte quality.
  • To determine if Mater is necessary for maintaining centromere cohesion during oocyte maturation.

Main Methods:

  • Compared Mater protein levels in oocytes from young and old mice using immunoblotting.
  • Utilized wild-type and Mater-null mice for cytogenetic karyotyping, time-lapse confocal microscopy, and immunofluorescence staining to assess centromere cohesion.

Main Results:

  • Mater protein levels were significantly decreased in oocytes from old mice compared to young mice.
  • Depletion of Mater resulted in reduced centromere cohesion, evidenced by precocious sister chromatid separation and chromosome misalignment during meiosis.
  • These findings indicate Mater's critical role in maintaining chromosomal integrity in aging oocytes.

Conclusions:

  • The maternal effect gene Mater plays a vital role in preventing age-related oocyte quality decline in mice.
  • Understanding Mater's mechanisms offers potential insights into strategies for mitigating age-related infertility.
  • Further research is needed to confirm the applicability of these findings to human oocytes.