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Updated: Mar 27, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Cassane diterpenes from the seed kernels of Caesalpinia sappan
Hai Xuan Nguyen1, Nhan Trung Nguyen1, Phu Hoang Dang1
1Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
Abstract:
Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.
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