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Updated: Mar 27, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical
Abdelrahman Y Fouda1, Sandeep Artham2, Azza B El-Remessy2
1Charlie Norwood VA Medical Center, and Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, and Georgia Regents University, Augusta, GA 30912, U.S.A. Clinical Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Abstract:
As our knowledge expands, it is now clear that the renin-angiotensin (Ang) system (RAS) mediates functions other than regulating blood pressure (BP). The RAS plays a central role in the pathophysiology of different neurovascular unit disorders including stroke and retinopathy. Moreover, the beneficial actions of RAS modulation in brain and retina have been documented in experimental research, but not yet exploited clinically. The RAS is a complex system with distinct yet interconnected components. Understanding the different RAS components and their functions under brain and retinal pathological conditions is crucial to reap their benefits. The aim of the present review is to provide an experimental and clinical update on the role of RAS in the pathophysiology and treatment of stroke and retinopathy. Combining the evidence from both these disorders allows a unique opportunity to move both fields forward.
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